|
Symbol Name ID |
C4b
complement C4B (Chido blood group) MGI:88228 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukopenia |
Recurrent sinusitis |
Pericarditis |
Lymphadenopathy |
Chronic active hepatitis |
Recurrent otitis media |
Glomerulonephritis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Recurrent pneumonia |
Serositis |
Reduced circulating CH50 activity |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Decreased circulating complement C4b concentration |
Anti-citrullinated protein antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Asthma |
Meningitis |
| Disease(s) Associated with C4A | |||||||||||||||||||||||||||||||
| complement component 4a deficiency | |||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||
| Disease(s) Associated with C4B | |||||||||||||||||||||||||||||||
| complement component 4b deficiency | |||||||||||||||||||||||||||||||
| rheumatoid arthritis | |||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||
| Mouse Phenotypes | immune system phenotype |
increased spleen weight |
increased neutrophil cell number |
increased macrophage cell number |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
increased spleen germinal center number |
abnormal immune system physiology |
abnormal humoral immune response |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
increased anti-single stranded DNA antibody level |
liver inflammation |
glomerulonephritis |
decreased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
decreased susceptibility to Coronaviridae infection |
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| Availability | Mouse Genotype | ||||||||||||||||||
| C4btm1Crr/C4btm1Crr | * | ||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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